Enola Holmes, much younger sister of detective Sherlock Holmes, must travel to London in disguise to unravel the disappearance of her missing mother.

Fourteen-year-old Enola Holmes, disguised as a beautiful woman, finds clues in floral bouquets as she searches for the missing Doctor Watson, a companion of her famous older brother, Sherlock.

In late nineteenth-century London, fourteen-year-old Enola Holmes, much younger sister of detective Sherlock Holmes, turns to Florence Nightingale for help when her investigation into the disappearance of a Crimean War widow grows cold.

When professional typist Letitia Glover is desperate to learn more about the fate of her twin sister Flossie, Enola enlists the help of her brother Sherlock and her friend Tewky to investigate Flossie's husband, the sudden death of his first wife, and the mysterious appearance of a black barouche.

Enola Holmes, now independent and pursuing her profession as a scientific perditorian, joins forces with her brother Sherlock to solve the mysterious disappearance of Wolcott Balestier, a friend of Rudyard Kipling, as they uncover the ruthless world of book publishing and seek to bring him back safely.