New York City is being threatened by a villainous bug who has inhabited the body of a farmer. The mission is to locate and exterminate the bug before it destroys the planet.

Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg and her daughter Sarah play a deadly game of cat-and-mouse with three intruders during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.